Pathology reviews 1989

Pulmonary Pathology Reviews

QuickScan Reviews in Pathology, May 30 2009

Background: There is growing interest in the laboratory detection of circulating tumor cells (CTCs) as surrogate markers for response to cancer chemotherapy, specifically breast, prostate, colon, and lung carcinomas. A single FDA-approved method (CellSearch) uses antibody-coated magnetic beads and semiautomated fluorescent microscopy. Investigators at Massachusetts General Hospital (MGH) are de...

QuickScan Reviews in Pathology, April 30 2009

Background: Autoimmune pancreatitis (AIP) is a newly characterized lesion in the differential diagnosis of a pancreatic head mass. Given its ability to simulate pancreatic cancer, AIP is a common diagnosis in false-positive Whipple resections presumed to contain a malignancy. Because steroids are highly effective, the preoperative diagnosis of AIP is now critical for avoiding unnecessary surger...

QuickScan Reviews in Pathology, August 30 2009

Background: Among chromosomal deletions and gains that are prognostically significant in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), unfavorable 17p deletions are the strongest predictor of outcome. Genetic abnormalities with lesser prognostic significance include del 11q 22.3, trisomy 12, del 13q14, and an additional locus as chromosome 13q34, all of which are routinely ...

QuickScan Reviews in Pathology, July 30 2009

Background: The RET (rearranged during transfection) proto-oncogene codes for a tyrosine kinase receptor that plays an important role in the developmental regulation of the kidney and nervous systems. Sporadic mutations in RET have been well documented in cases of papillary thyroid carcinoma (PTC), the most common being RET/PTC 1 and RET/PTC 3. Although originally thought to be a specific tumor...